ISO Is a Deadly Reason for Concern

There are rising concerns about the emergence of new synthetic opioids that may be just as deadly as fentanyl. Recently, reports have shown that isotonitazene has replaced heroin as the drug most often associated with fatal overdoses.

ISO, or isotonitazene, is now the deadliest illegal drug in the United States, surpassing fentanyl. Due to its relative novelty, the drug was not included on official prohibited drug lists, making it available for sale and purchase on underground markets.

Numerous overdoses have been linked to ISO, a substance that specialists believe to be 20-100 times as strong as fentanyl. ISO is available as a free base and a salt, as well as in brown, yellow, and white powder forms.


It's conceivable that consumers will be deceived into believing they're buying a different drug when they buy ISO since it may also be taken orally in liquid form. If you swallow ISO, it will make its way to your brain and affect your neurological system. ISO is lethal in large doses because it slows and stops respiration.


ISO is a relatively new substance, making it difficult for medical practitioners and law enforcement to identify whether or not it is the cause of an overdose. ISO cannot be identified by conventional drug testing, delaying the administration of the life-saving antidote Narcan in the event of an overdose.


The drug cause 40-50 deaths per month in 2020, ranking it among the deadliest substances, making it a priority for strict regulation as a Schedule I narcotic (meaning it has no medically accepted use and has a high risk of misuse). Heroin and LSD have the same categorization as Schedule I drug.


After being illegally produced in China, the chemical was sent to Mexico and smuggled into the United States. Belgian and German scientists first developed the substance for therapeutic and research objectives, but it was finally abandoned owing to its extraordinary potency.


Medical experts say it is now being mixed with cocaine to produce a dangerous poison, whether ingested orally or applied topically.


The FDA has never approved ISO for medical use. Consequently, studies examining possible side effects are few. According to some users, ISO may cause side effects such as sleepiness, trouble breathing, nausea, and vomiting.



There is no way to know whether ISO will have unintended consequences since it has not been tested in humans. ISO isn't alone among medications in its class in having the potential to cause cardiovascular disease, neurological diseases, and other chronic health issues. ISO presents a substantially higher risk of deadly overdose when combined with other drugs.


If you or someone you know is experiencing any of the issues addressed in this article, please don't hesitate to call the Substance Abuse and Mental Health Services Administration (1-800-662-HELP). To find a facility that cares about the health and rehabilitation of those with opioid use disorders, you may contact detox and rehab centers like Wish Recovery.

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